Detalhe da pesquisa
1.
Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development.
Annu Rev Biochem
; 86: 305-331, 2017 06 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28375741
2.
A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.
Blood
; 140(19): 2053-2062, 2022 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35576529
3.
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Blood Cells Mol Dis
; 95: 102660, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35366607
4.
Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies.
Drug Metab Dispos
; 49(10): 870-881, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34321251
5.
AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.
Haematologica
; 106(1): 238-249, 2021 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31974203
6.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Blood
; 130(11): 1347-1356, 2017 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28760888
7.
Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy.
Blood
; 137(21): 2997-3001, 2021 05 27.
Artigo
Inglês
| MEDLINE | ID: mdl-33690814
8.
Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in ß-thalassemic mice.
Haematologica
; 108(9): 2535-2541, 2023 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36794508
9.
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
J Inherit Metab Dis
; 39(6): 807-820, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27469509
10.
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
J Biol Chem
; 289(20): 13717-25, 2014 May 16.
Artigo
Inglês
| MEDLINE | ID: mdl-24668804
11.
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.
Cancer Cell
; 12(2): 115-30, 2007 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-17692804
12.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature
; 462(7274): 739-44, 2009 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-19935646
13.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22922757
14.
Structure-Based Design of AG-946, a Pyruvate Kinase Activator.
ChemMedChem
; 19(5): e202300559, 2024 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38109501
15.
Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis.
JCI Insight
; 8(20)2023 Oct 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37676741
16.
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.
Blood
; 116(9): 1515-23, 2010 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-20525923
17.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature
; 465(7300): 966, 2010 Jun 17.
Artigo
Inglês
| MEDLINE | ID: mdl-20559394
18.
Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.
Proc Natl Acad Sci U S A
; 105(52): 20798-803, 2008 Dec 30.
Artigo
Inglês
| MEDLINE | ID: mdl-19104039
19.
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J Med Chem
; 64(8): 4430-4449, 2021 04 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33829783
20.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model.
J Clin Invest
; 131(10)2021 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33822774